Vitreous protein networks around ANG2 and VEGF in proliferative diabetic retinopathy and the differential effects of aflibercept versus bevacizumab pre-treatment.
Sci Rep (2022) 12:21062.

Quantitative Assessment of the Apical and Basolateral Membrane Expression of VEGFR2 and NRP2 in VEGF-A-stimulated Cultured Human Umbilical Vein Endothelial Cells.
Histochem Cytochem (2022) 70:557-569.

Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline.
Trends Endocrinol Metab (2022) 33:50-71.

PDGF as an Important Initiator for Neurite Outgrowth Associated with Fibrovascular Membranes in Proliferative Diabetic Retinopathy.
Curr Eye Res (2022) 47:277-286.

Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease.
Prog Retin Eye Res (2022) 87:100994.


miRNA Levels as a Biomarker for Anti-VEGF Response in Patients with Diabetic Macular Edema.
J Pers Med (2021) 11:1297.

The Role of Heparan Sulfate and Neuropilin 2 in VEGFA Signaling in Human Endothelial Tip Cells and Non-Tip Cells during Angiogenesis In Vitro.
Cells (2021) 10:926

Angiogenesis in gynecological cancers and the options for anti-angiogenesis therapy.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (2021) 1875:188446


microRNA Expression Profile in the Vitreous of Proliferative Diabetic Retinopathy Patients and Differences from Patients Treated with Anti-VEGF Therapy.
Trans Vis Sci Tech (2020) 9:16

IGF-binding proteins 3 and 4 are regulators of sprouting angiogenesis.
Mol Biol Rep (2020) 47:2561-2572


The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis.
Scientific Reports (2019) 9:12608

Endothelial tip cells in vitro are less glycolytic and have a more flexible response to metabolic stress than non-tip cells.
Scientific Reports (2019) 9:10414

Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression.
Br. J. Cancer (2019) 121:139–149

Expression patterns of endothelial permeability pathways in the development of the blood-retinal barrier in mice.
FASEB J. (2019) 33:5320-5333

Glucocorticoids exert differential effects on the endothelium in an in vitro model of the blood-retinal barrier.
Acta Ophthalmol (2019) 97:214-224.


The role of plasmalemma vesicle-associated protein in pathological breakdown of blood–brain and blood–retinal barriers: potential novel therapeutic target for cerebral edema and diabetic macular edema.
Fluids and Barriers of the CNS (2018) 15:24.

IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers
Angiogenesis (2018) 1:823-836

Consensus guidelines for the use and interpretation of angiogenesis assays.
Angiogenesis (2018) 21:425-532.

Spatial and temporal recruitment of the neurovascular unit during development of the mouse blood-retinal barrier.
Tissue and Cell (2018) 52:42-50.

Involvement of the ubiquitin-proteasome system in the expression of extracellular matrix genes in retinal pigment epithelial cells.
Biochem Biophys Rep (2018)13:83-92.


Identification of proteins associated with clinical and pathological features of proliferative diabetic retinopathy in vitreous and fibrovascular membranes.
PLoS One (2017) 12:e0187304.

Modulation of the Proteasome Pathway by Nano-Curcumin and Curcumin in Retinal Pigment Epithelial Cells.
Ophthalmic Res (2017) 59:98-109.

Is leukostasis a crucial step or epiphenomenon in the pathogenesis of diabetic retinopathy?
J Leukoc Biol (2017) 102:993-1001.

TNFα-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3',5'-Cyclic Adenosine Monophosphate Levels.
Invest Ophthalmol Vis Sci (2017) 58:3496-3505.


Computational Screening of Tip and Stalk Cell Behavior Proposes a Role for Apelin Signaling in Sprout Progression.
PLoS One (2016) 11:e0159478.

Association of Circulating Markers With Outcome Parameters in the Bevacizumab and Ranibizumab in Diabetic Macular Edema Trial.
Invest Ophthalmol Vis Sci (2016) 57:6234-6241.

CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.
PLoS One (2016) 11:e0157902.

Role of sulfatase 2 in lipoprotein metabolism and angiogenesis.
Curr Opin Lipidol (2016) 27:181-6.

Plasmalemma Vesicle Associated Protein Has a Key Role in Blood-Retinal Barrier Loss.
Am J Pathol (2016) 186:1044-54.


Tip Cells in Angiogenesis
In: eLS. John Wiley & Sons Ltd, Chichester.

The role of CTGF in diabetic retinopathy.
Exp Eye Res (2015) 133:37-48.


Computational Screening of Angiogenesis Model Variants Predicts that Differential Chemotaxis Helps Tip Cells Move to the Sprout Tip and Accelerates Sprouting.
arXiv:1409.5895 [q-bio.CB]

Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy.
Exp Eye Res (2014)122:123-31

Connective tissue growth factor is involved in structural retinal vascular changes in long-term experimental diabetes.
J Histochem Cytochem (2014) 62:109-18.


Complement factor C3a alters proteasome function in human RPE cells and in an animal model of age-related RPE degeneration.
Invest Ophthalmol Vis Sci (2013) 54:6489-501.

Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. Review.
Prog Retin Eye Res (2013) 34:19-48.

Endothelial tip cells in ocular angiogenesis: potential target for anti-angiogenesis therapy. Review.
J Histochem Cytochem (2013) 61:101-15.

Vitreous TIMP-1 levels associate with neovascularization and TGF-β2 levels but not with fibrosis in the clinical course of proliferative diabetic retinopathy.
J Cell Commun Signal (2013) 7:1-9.


A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy.
Br J Ophthalmol (2012) 96:587-90.

CD34 marks angiogenic tip cells in human vascular endothelial cell cultures.
Angiogenesis (2012) 15:151-63.

A novel co-culture model of the blood-retinal barrier based on primary retinal endothelial cells, pericytes and astrocytes.
Exp Eye Res (2012) 96:181-90.

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